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Nursing Open launches!

April 9, 2014

Nursing Open launch cover

Wiley is delighted to announce the launch of its newest open access journal, Nursing Open, the first open access journal to publish high-quality articles covering all aspects of nursing, from education and research through to policy and practice.

Editor Roger Watson was present at the launch which took place at the prestigious Royal College of Nursing’s International Research Conference last week.  Professor Watson is based at the University of Hull and has extensive experience working with older people, and in particular the feeding and nutritional problems faced by patients with dementia.

“Nursing Open aims to provide integrity and speed in publishing a wide range of high quality nursing scholarship and, within a short time, to be the preferred destination for open access articles in nursing.” said Professor Watson.

In what could be one of the most important launches in the nursing field for years, Nursing Open aims to have a positive impact on health, from local and regional to national and global scales.  The journal provides authors with a new platform for the rapid dissemination of research on nursing and midwifery practice, and will make a real and valuable contribution towards the science of nursing. The journal will publish articles under the Creative Commons Attribution (CC BY) License, allowing authors to comply with Open Access Mandates.

Nursing Open is now open for submissions. For more information on the journal, including how to submit an article, please visit the website at: www.nursingopenjournal.com

Molecular Genetics & Genomic Medicine Volume 2 Issue 2 is Published!

March 14, 2014

MGGM Molecular Genetics & Genomic Medicine has now published its next issue. Editor-in-Chief: Max Muenke introduces his editorial highlights: “This issue includes an Invited Commentary on newborn screening, along with articles on association of the GPR88 gene and major psychoses and TNNT1 mutations in nemaline myopathy.  It also features the first article in our series Genetics and Genomic Medicine around the World, this month focusing on Israel.  Highlights of the issue include ‘Novel IFT122 mutation associated with impaired ciliogenesis and cranioectodermal dysplasia’ and ‘Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations.

Novel IFT122 mutation associated with impaired ciliogenesis and cranioectodermal dysplasia by Anas M. Alazami, Mohammed Zain Seidahmed, Fatema Alzahrani, Adam O. Mohammed and Fowzan S. Alkuraya. Abstract: Cranioectodermal dysplasia (CED) is a very rare autosomal recessive disorder characterized by a recognizable craniofacial profile in addition to ectodermal manifestations involving the skin, hair, and teeth. Four genes are known to be mutated in this disorder, all involved in the ciliary intraflagellar transport confirming that CED is a ciliopathy. In a multiplex consanguineous family with typical CED features in addition to intellectual disability and severe cutis laxa, we used autozygosity-guided candidate gene analysis to identify a novel homozygous mutation in IFT122, and demonstrated impaired ciliogenesis in patient fibroblasts. This report on IFT122 broadens the phenotype of CED and expands its allelic heterogeneity.

Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations by Tian Yang, Zhonglin Jia, Whitney Bryant-Pike, Anand Chandrasekhar, Jeffrey C. Murray, Bernd Fritzsch and Alexander G. Bassuk. Abstract: Palate development is shaped by multiple molecular signaling pathways, including the Wnt pathway. In mice and humans, mutations in both the canonical and noncanonical arms of the Wnt pathway manifest as cleft palate, one of the most common human birth defects. Our results reveal that in mice and humans PRICKLE1 directs palate morphogenesis; our results also uncouple Prickle1 function from Vangl2 function. Together, these findings suggest mouse and human palate development is guided by PCP-Prickle1 signaling that is probably not downstream of Vangl2. 

The journal also publishes Genetics and Genomic Medicine around the World. Below is the first article of this type, this month focusing on Israel.
Genetics and genomic medicine in Israel” by Joël Zlotogora

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MicrobiologyOpen Issue 3:1 Published Online

February 18, 2014

MicrobiologyOpenMicrobiologyOpen has published its latest online issue. 13 new articles are fully open access: free to read, download and share.

MicrobiologyOpen is a broad scope, peer reviewed journal delivering rapid decisions and fast publication of microbial science.  The journal gives priority to reports of quality research, pure or applied, that further our understanding of microbial interactions and microbial processes.

Editor-in-Chief, Pierre Cornelis has highlighted the papers below as of particular interest:

purple_lock_openUnsuspected pyocyanin effect in yeast under anaerobiosis
Rana Barakat, Isabelle Goubet, Stephen Manon, Thierry Berges and Eric Rosenfeld

Summary: Toxicity of pyocyanin (PYO) was investigated under aerobiosis and anaerobiosis in several wild-type and mutant strains of the yeast Saccharomyces cerevisiae and also in Candida albicans. PYO is toxic for actively respiring cells but its toxicity was found to be important and even higher under anaerobiosis. This indicates that PYO effect can be mediated by other phenomenon than oxidative stress and respiratory disturbance.

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Serum influences the expression of Pseudomonas aeruginosa quorum-sensing genes and QS-controlled virulence genes during early and late stages of growth
Cassandra Kruczek, Uzma Qaisar, Jane A. Colmer-Hamood and Abdul N. Hamood

Summary: In this study, we demonstrated that serum reduces the expression of different QS genes at early stages of growth but increases their expression at late stages of growth of P. aeruginosa. A similar phenomenon was observed regarding the production of autoinducers and the expression of QS-controlled virulence genes. Serum also differentially regulated the expression several positive and negative regulators of the QS systems. While the mechanism by which serum affects QS at early stage of growth is not yet known, our results suggest that serum accomplishes its effect at late stages of growth through the virulence factor regulator vfr

purple_lock_openVisualization of VirE2 protein translocation by the Agrobacterium type IV secretion system into host cells
Philippe A. Sakalis, G. Paul H. van Heusden and Paul J. J. Hooykaas

Summary: Here we report the direct visualization of VirE2 protein translocation from Agrobacterium into host cells. To this end we cocultivated Agrobacterium strains expressing VirE2 tagged with one part of a fluorescent protein with host cells expressing the complementary part. Fluorescent filaments became visible in recipient cells 20-25 hours after the start of the cocultivation indicative of VirE2 protein translocation.

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American Geophysical Union and Wiley Launch New Open Access Journal, Earth and Space Science

February 10, 2014

The American Geophysical Union (AGU) and John Wiley & Sons, Inc., today announced the creation of a new all open access peer-reviewed journal, Earth and Space Science.

Marking AGU’s second new open access journal in the last 12 months, Earth Space and Science is the only journal that reflects the expansive range of science represented by AGU’s 62,000 members, including all of the Earth, planetary, and space sciences, and related fields in environmental science, geoengineering, space engineering, and biogeochemistry.
 
>> Read the full press release here <<

Earth and Space Science joins a prestigious portfolio of research publications that are governed by AGU’s rigorous peer review process. This includes the highly ranked Geophysical Research Letters and Journal of Geophysical Research – Atmospheres, and Earth’s Future—an innovative open access publication that features trans-disciplinary research, editorials, and essays emphasizing the Earth as an interactive, evolving system under the influence of the human enterprise—which was successfully launched in late 2013.

The journal will publish articles under the Creative Commons Attribution License enabling authors to be fully compliant with open access requirements of funding organizations where applicable. The publication fee will be competitive with those of other broad open access journals.

A search is now underway for Earth and Space Science’s inaugural editor in chief, who will lead a team of preeminent academic editors who are closely connected to their communities. 

Additional information on Earth and Space Science is available at http://earthspacescience.agu.org.

Read the February Issue of Evolutionary Applications Online!

January 29, 2014
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eva_7_2_coverThe February Issue of Evolutionary Applications has been published online. This issue features an image of a lone grizzly bear in Alberta, Canada, which relates to a study by Shafer and colleagues linking the genotype, ecotype, and phenotype in grizzly bears (Ursus arctos). Toward this end, this issue also launches a new series of research highlights that will offer brief synopses of new work with direct relevance to readers of Evolutionary Applications from across other journals with the aim of exploring the breadth of potential applications of evolutionary theory from across fields and disciplines. The Editor-in-Chief Louis Bernatchez has highlighted the following articles as of particular interest:

purple_lock_open Genomic selection for recovery of original genetic background from hybrids of endangered and common breeds by Carmen Amador, Ben J. Hayes and Hans D. Daetwyler

Summary: The authors present two genomic selection strategies, employing genome-wide DNA markers, to recover the genomic content of the original endangered population from admixtures. They also compare the efficiency of both strategies using empirical 50K SNP array data from sheep breeds.

purple_lock_open Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours by Beata Ujvari, Anne-Maree Pearse, Kate Swift, Pamela Hodson, Bobby Hua, Stephen Pyecroft, Robyn Taylor, Rodrigo Hamede, Menna Jones, Katherine Belov and Thomas Madsen

Summary: The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to study cancer evolution in vivo. Since it was first observed in 1996, this transmissible cancer has caused local population declines by 90%. In this study the authors focus on the evolutionary response of DFTD to a disease suppression trial.  The results reveal that DFTD has the capacity to rapidly respond to novel human-induced selective regimes and that disease eradication may result in novel tumour adaptations.

purple_lock_open Linking genotype, ecotype, and phenotype in an intensively managed large carnivore by Aaron B. A. Shafer, Scott E. Nielsen, Joseph M. Northrup and Gordon B. Stenhouse

Summary: In this study, integrated GPS habitat use data and genetic profiling were used to determine the influence of habitat and genetics on fitness proxies (mass, length, and body condition) in a threatened population of grizzly bears (Ursus arctos) in Alberta, Canada. The authors found that homozygosity had a positive effect on fitness these proxies, which may be indicative of outbreeding depression unintentionally caused by massive translocations of bears over large geographic distances.

We encourage you to submit papers applying concepts from evolutionary biology to address biological questions of health, social and economic relevance across a vast array of applied disciplines. We also welcome submissions of papers making use of modern genomics or other molecular methods to address important questions in an applied evolutionary framework. For more information please visit the aims and scopes page.

Submit your article to Evolutionary Applications here >

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ChemistryOpen hot off the press!

January 24, 2014

Chemopen The current Issue of ChemistryOpen includes an exciting Communication on a Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor. Eric Meggers, Holger Steuber and co-workers present an organometallic inhibitor scaffold for Pim kinases. These are interesting targets for cancer therapy as they are overexpressed in various human cancers. Usually kinase inhibitors are ATP competitive. However, as shown in a cocrystal structure with Pim1, their presented organometallic compound (based on a cyclometalated 1,8-phenanthrolin-7(8H)-one ligand) presents an unexpected non-hinge binding scaffold and could be a suitable lead structure for the development of potent and selective non-hinge-binding ATP-competitive inhibitors of Pim kinases.

In the Full Paper of this issue, Giampaolo Barone, F. Matthias Bickelhaupt and co-workers report on their dispersion-corrected density functional studies for the investigation of the DNA double helix structure. They calculate how B-DNA structure stability correlates with its nucleic acid composition and are able to show that the stability of the structure not only depends on the number of hydrogen bonds in Watson-Crick base pairs but also depends on the base pair order and orientation.

The newest contribution to ChemistryOpen‘s Thesis Treasury from Rafael Gramage-Doria features metallocyclodextrins. In his thesis he found that upon encapsulation of metal fragments in the cavity of a b-cyclodextrin-derived diphosphane, otherwise unstable metal species can be formed and coordination processes can be slowed down, which allows investigating mechanistic pathways for carbon-carbon bond-forming reactions.

To read all open-access full-text articles, visit our homepage!

Onwards and Upwards for Wiley Open Access

January 22, 2014

2013 was quite a year for Wiley Open Access, with the addition of 16 new open access journals to our portfolio,  OnlineOpen orders reaching an all time high and the significant increase in institutions with Wiley Open Access Accounts.

2014 is also set to be a year of growth. Wiley will be publishing 33 journals as part of the Wiley Open Access program, many in partnership with societies.  In addition, over 1,300 of our subscription journals now offer the hybrid Online Open option to authors. We have recently launched or are planning to launch the following new Open Access journals:

In addition, the following journals ‘flipped’  from the subscription model to Open Access on 1st January 2014:

The complete list of 2014 Journal Titles, Changes and Collections is available on Wiley Online Library.

Evolutionary Applications SPECIAL ISSUE: Climate change, adaptation and phenotypic plasticity

January 20, 2014
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eva_v7_i1_OC_RevThe January Special issue of Evolutionary Applications edited by guest editors Juha Merilä and Andrew Hendry, reviews the available literature that studies the responses to climate change in a large variety of taxa, including terrestrial and aquatic phytoplankton, plants and invertebrates, as well as all classes of vertebrates, including fish, amphibians, reptiles birds and mammals. Clearly this Special Issue is the most updated and exhaustive coverage on this crucial topic. The cover image features a collage highlighting some of the species that have been the subject of focus in this issue for their response to climate change. The Editor-in-Chief Louis Bernatchez has highlighted the following Special Issue articles as of particular interest:

purple_lock_open Climate change, adaptation, and phenotypic plasticity: the problem and the evidence
by Juha Merilä and Andrew P. Hendry

Summary:
This perspective article examines the levels of inference employed in studies where recorded phenotypic changes in natural populations have been attributed to climate change. Based on the reviews from this Special Issue, Merilä and Hendry conclude that evidence for genetic adaptation to climate change has been found in some systems, but remains relatively scarce compared to evidence for phenotypic plasticity. It is apparent that additional studies employing better inferential methods are required before drawing further conclusions.

purple_lock_openRapid evolution of quantitative traits: theoretical perspectives by Michael Kopp and Sebastian Matuszewski

Summary:
 In this review and syntheses article the authors review the theoretical models of rapid evolution in quantitative traits, to shed light on the potential for adaptation to climate change. In particular, the authors demonstrate how survival can be greatly facilitated by phenotypic plasticity, and how heritable variation in plasticity can further speed up genetic evolution.

purple_lock_open Climate warming and Bergmann’s rule through time: is there any evidence? by Celine Teplitsky and Virginie Millien

Summary:
In this article the authors investigate the hypothesis that the climate warming causes a reduction in body size. This hypothesis originates from Bergmann’s rule, whereby species in warmer climates exhibit a smaller body size when compared to endotherms found in colder climates. Reviewing the literature the authors find weak evidence for changes in body size through time as predicted by Bergmann’s rule.

We do hope you enjoy reading this month’s Special Issue, and encourage you to submit papers applying concepts from evolutionary biology to address biological questions of health, social and economic relevance across a vast array of applied disciplines. We also welcome submissions of papers making use of modern genomics or other molecular methods to address important questions in an applied evolutionary framework. For more information please visit the aims and scopes page.

Submit your article to Evolutionary Applications here >

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Molecular Genetics & Genomic Medicine Volume 2 Issue 1 is Published!

January 10, 2014

MGGM Molecular Genetics & Genomic Medicine has now published its next issue. Editor-in-Chief: Max Muenke introduces his editorial highlights: “Our second volume continues with the high-quality manuscripts that you have come to expect, with articles on Usher syndrome exome sequencing, identification of novel mutations in Donohue syndrome, and a revision of the mitochondrial tRNA pathogenicity scoring system.  In addition, we announce a new feature, “Genetics and Genomic Medicine around the World”.   Highlights of the first issue of Volume 2 include “Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency” and “Candidate disease gene prediction using Gentrepid: application to a genome-wide association study on coronary artery disease”.

Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency by Sali M. K. Farhan, Jian Wang, John F. Robinson, Piya Lahiry, Victoria M. Siu, Chitra Prasad, Jonathan B. Kronick, David A. Ramsay, C. Anthony Rupar and Robert A. Hegele. Summary: We describe infantile mitochondrial complex II/III deficiency, a novel autosomal recessive mitochondrial disease characterized by lactic acidemia, hypotonia, respiratory chain complex II and III deficiency, multisystem organ failure, and abnormal mitochondria. Through autozygosity mapping, exome sequencing, in silico analyses, population studies, and functional tests, we identified c.215G>A, p.Arg72Gln in NFS1 as the likely causative mutation. We describe the first disease in man likely caused by deficiency in NFS1, a cysteine desulfurase that is implicated in respiratory chain function and iron maintenance by initiating Fe-S cluster biosynthesis.

Candidate disease gene prediction using Gentrepid: application to a genome-wide association study on coronary artery disease by Sara Ballouz, Jason Y. Liu, Martin Oti, Bruno Gaeta, Diane Fatkin, Melanie Bahlo and Merridee A. Wouters. Summary: The application of a candidate disease gene prediction tool to a genome-wide association study on coronary artery disease revealed numerous novel candidates. The method and results of this analysis using protein networks and protein functional domains are presented here, along with the candidates.

The journal now also publishes the new feature Genetics and Genomic Medicine around the World. Below is the editorial explaining this new feature:
Genetics and Genomic Medicine around the World” by Maximilian Muenke

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Read the inaugural issue of Pharmacology Research & Perspectives

December 19, 2013

53417-PRP-journalWe are pleased to announce that Pharmacology Research & Perspectives has now published its inaugural issue. Pharmacology Research & Perspectives is a new journal from the British Pharmacological Society (BPS) and the American Society for Pharmacology & Experimental Therapeutics (ASPET) and promotes research in all areas of pharmacology.   
 
The editor’s choice articles from the inaugural issue are:  
  
purple_lock_openGreen fluorescent protein fused to peptide agonists of two dissimilar G protein-coupled receptors: novel ligands of the bradykinin B2 (rhodopsin family) receptor and parathyroid hormone PTH1 (secretin family) receptor
Xavier Charest-Morin, Jean-Philippe Fortin, Marie-Thérèse Bawolak, Robert Lodge and François Marceau    

purple_lock_openEffects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo
Seth C. Hopkins, Una C. Campbell, Michele L. R. Heffernan, Kerry L. Spear, Ross D. Jeggo, David C. Spanswick, Mark A. Varney and Thomas H. Large    

purple_lock_open Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway
Fumiya Ishizuka, Masamitsu Shimazawa, Yusuke Egashira, Hiromi Ogishima, Shinsuke Nakamura, Kazuhiro Tsuruma and Hideaki Hara
 

Read inaugural issue

 Pharmacology Research & Perspectives invites authors to submit research articles and invites submission of several types of special articles. These are:
1. Target validation – publication of negative findings including preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development
2. Drug discovery reviews – strategy, hypotheses and data resulting in a successful therapeutic drug
3. Frontiers in translational medicine – drug and target validation for an unmet therapeutic need
4. Pharmacological hypotheses – reviews that are oriented to inform a novel hypothesis

All articles are published under a Creative Commons License and comply with all open access mandates.

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