Wiley today launched Evidence-based Preclinical Medicine (EBPM), a new open access journal and the first of its kind dedicated to publishing systematic review protocols and systematic reviews which summarise data from animal studies on subjects relevant to human health. The launch of EBPM consolidates Wiley’s position as the leading publisher in evidence-based medicine.
Systematic reviews are a form of meta-analysis, identifying, appraising, selecting and synthesising all high quality research evidence relevant to a specific question. EBPM’s synthesis of preclinical evidence will improve evaluation of the potential success of future clinical trials, improving the reliability and value of medical research.
The journal is edited by Associate Professor David Howells, of the Florey Institute of Neuroscience and Mental Health, and Professor Malcolm Macleod of the University of Edinburgh. ‘Evidence-based Preclinical Medicine aims to be more than just a journal’ said Professor Macleod. ‘By providing a foundation of pre-clinical evidence we can escape the enthusiasms and vested interests that can distort the application of research from animals to humans’.
The journal has developed a helpdesk to guide practitioners through the processes of systematic review and to help authors prepare their study datasets for publication. EBPM also publishes protocols describing the proposed approach for a systematic review, enabling readers to distinguish between hypothesis and evidence-based observations.
For more information visit: www.evidencebasedpreclinicalmedicine.com
Wiley is excited to announce that Veterinary Medicine and Science has launched! This is a new, international, open access journal publishing original, quality peer-reviewed research. The journal covers all aspects of medicine and science related to zoo, production and companion animals.
Veterinary Medicine and Science aims to provide a platform where authors can submit interesting and original work related to the fields of fundamental and clinical veterinary medicine and science. The journal will provide a global forum where the best research is made available as quickly as possible.
And because the journal is fully open access, research is available to all, with no restrictions. All articles published to the journal are published under the Creative Commons Attribution Licence, allowing authors to comply with Open Access Mandates.
Editor-in-Chief, Ed Hall, is based at the University of Bristol Veterinary School, where he heads up the Comparative and Clinical Research Group. His particular research and clinical interests are small animal gastroenterology and endoscopy.
Veterinary Medicine and Science is now open for submissions. For more information, and to find out how to submit your work, please visit the website here.
Wiley is delighted to announce the launch and publication of the inaugural first issue of one of its newest open access journals, Regeneration. The journal is the first, world-class publication of its kind dedicated to the rapidly expanding field of regeneration and repair.
Regeneration aims to become the journal of choice for those looking to publish top quality, original research related to regeneration and repair in its many forms, and in all relevant animal and plant species.
Read Editor-in-Chief Susan Bryant’s inaugural editorial here.
Read the first published articles here:
Experimentally induced metamorphosis in axolotls reduces regenerative rate and fidelity James R. Monaghan, Adrian C. Stier, François Michonneau, Matthew D. Smith, Bret Pasch, Malcolm Maden and Ashley W. Seifert
Salamanders regenerate limbs throughout life, but it is unclear how body size, aging, or metamorphosis affects regeneration. Here, we show that metamorphosis has a negative impact on limb regeneration rate and fidelity by limiting cell proliferation in metamorphic limbs.
Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules Ping Wu, Lorenzo Alibardi and Cheng-Ming Chuong
Reptile scale development and regeneration occur through different processes. A–D, embryonic reptile scales develop from a flat bilayer epidermis to symmetric scale anlagen to asymmetric scale anlagen and further to mature scales. E–H, skin regenerates scales from flat wound epidermis to peg formation to elongating pegs and further to differentiating pegs. Despite these differences, they share similarities in proliferation patterns, epithelial–mesenchymal interactions and molecular modules.
Position-specific induction of ectopic limbs in non-regenerating blastemas on axolotl forelimbs Catherine McCusker, Jeffrey Lehrberg and David Gardiner
To test the hypothesis that retinoid acid (RA) reprograms the positional information in limb blastemas cells to a singular posterior-ventral-proximal (PVPr) identity, we treated blastemas at different positions on the limb circumference to determine whether ectopic limbs formed. We observed that RA treatment of blastemas in anterior and dorsal locations, but not posterior and ventral locations, resulted in the induction of complete ectopic limbs. These findings are consistent with the hypothesis that RA treatment reprograms the information in blastema cells to the PVPr position on the limb, and demonstrate that RA can be used to induce a regenerative response in anterior and dorsally located non-regenerative wounds.
We would like to invite you to submit your research paper to Regeneration at www.regenerationjournal.com. All authors retain copyright on their articles and all articles are fully open access upon publication.
Wiley is delighted to announce the launch of its newest open access journal, Nursing Open, the first open access journal to publish high-quality articles covering all aspects of nursing, from education and research through to policy and practice.
Editor Roger Watson was present at the launch which took place at the prestigious Royal College of Nursing’s International Research Conference last week. Professor Watson is based at the University of Hull and has extensive experience working with older people, and in particular the feeding and nutritional problems faced by patients with dementia.
“Nursing Open aims to provide integrity and speed in publishing a wide range of high quality nursing scholarship and, within a short time, to be the preferred destination for open access articles in nursing.” said Professor Watson.
In what could be one of the most important launches in the nursing field for years, Nursing Open aims to have a positive impact on health, from local and regional to national and global scales. The journal provides authors with a new platform for the rapid dissemination of research on nursing and midwifery practice, and will make a real and valuable contribution towards the science of nursing. The journal will publish articles under the Creative Commons Attribution (CC BY) License, allowing authors to comply with Open Access Mandates.
Nursing Open is now open for submissions. For more information on the journal, including how to submit an article, please visit the website at: www.nursingopenjournal.com
Molecular Genetics & Genomic Medicine has now published its next issue. Editor-in-Chief: Max Muenke introduces his editorial highlights: “This issue includes an Invited Commentary on newborn screening, along with articles on association of the GPR88 gene and major psychoses and TNNT1 mutations in nemaline myopathy. It also features the first article in our series Genetics and Genomic Medicine around the World, this month focusing on Israel. Highlights of the issue include ‘Novel IFT122 mutation associated with impaired ciliogenesis and cranioectodermal dysplasia’ and ‘Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations’.
Novel IFT122 mutation associated with impaired ciliogenesis and cranioectodermal dysplasia by Anas M. Alazami, Mohammed Zain Seidahmed, Fatema Alzahrani, Adam O. Mohammed and Fowzan S. Alkuraya. Abstract: Cranioectodermal dysplasia (CED) is a very rare autosomal recessive disorder characterized by a recognizable craniofacial profile in addition to ectodermal manifestations involving the skin, hair, and teeth. Four genes are known to be mutated in this disorder, all involved in the ciliary intraflagellar transport confirming that CED is a ciliopathy. In a multiplex consanguineous family with typical CED features in addition to intellectual disability and severe cutis laxa, we used autozygosity-guided candidate gene analysis to identify a novel homozygous mutation in IFT122, and demonstrated impaired ciliogenesis in patient fibroblasts. This report on IFT122 broadens the phenotype of CED and expands its allelic heterogeneity.
Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations by Tian Yang, Zhonglin Jia, Whitney Bryant-Pike, Anand Chandrasekhar, Jeffrey C. Murray, Bernd Fritzsch and Alexander G. Bassuk. Abstract: Palate development is shaped by multiple molecular signaling pathways, including the Wnt pathway. In mice and humans, mutations in both the canonical and noncanonical arms of the Wnt pathway manifest as cleft palate, one of the most common human birth defects. Our results reveal that in mice and humans PRICKLE1 directs palate morphogenesis; our results also uncouple Prickle1 function from Vangl2 function. Together, these findings suggest mouse and human palate development is guided by PCP-Prickle1 signaling that is probably not downstream of Vangl2.
The journal also publishes Genetics and Genomic Medicine around the World. Below is the first article of this type, this month focusing on Israel.
“Genetics and genomic medicine in Israel” by Joël Zlotogora
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MicrobiologyOpen is a broad scope, peer reviewed journal delivering rapid decisions and fast publication of microbial science. The journal gives priority to reports of quality research, pure or applied, that further our understanding of microbial interactions and microbial processes.
Editor-in-Chief, Pierre Cornelis has highlighted the papers below as of particular interest:
Unsuspected pyocyanin effect in yeast under anaerobiosis
Rana Barakat, Isabelle Goubet, Stephen Manon, Thierry Berges and Eric Rosenfeld
Summary: Toxicity of pyocyanin (PYO) was investigated under aerobiosis and anaerobiosis in several wild-type and mutant strains of the yeast Saccharomyces cerevisiae and also in Candida albicans. PYO is toxic for actively respiring cells but its toxicity was found to be important and even higher under anaerobiosis. This indicates that PYO effect can be mediated by other phenomenon than oxidative stress and respiratory disturbance.
Serum influences the expression of Pseudomonas aeruginosa quorum-sensing genes and QS-controlled virulence genes during early and late stages of growth
Cassandra Kruczek, Uzma Qaisar, Jane A. Colmer-Hamood and Abdul N. Hamood
Summary: In this study, we demonstrated that serum reduces the expression of different QS genes at early stages of growth but increases their expression at late stages of growth of P. aeruginosa. A similar phenomenon was observed regarding the production of autoinducers and the expression of QS-controlled virulence genes. Serum also differentially regulated the expression several positive and negative regulators of the QS systems. While the mechanism by which serum affects QS at early stage of growth is not yet known, our results suggest that serum accomplishes its effect at late stages of growth through the virulence factor regulator vfr.
Visualization of VirE2 protein translocation by the Agrobacterium type IV secretion system into host cells
Philippe A. Sakalis, G. Paul H. van Heusden and Paul J. J. Hooykaas
Summary: Here we report the direct visualization of VirE2 protein translocation from Agrobacterium into host cells. To this end we cocultivated Agrobacterium strains expressing VirE2 tagged with one part of a fluorescent protein with host cells expressing the complementary part. Fluorescent filaments became visible in recipient cells 20-25 hours after the start of the cocultivation indicative of VirE2 protein translocation.
Marking AGU’s second new open access journal in the last 12 months, Earth Space and Science is the only journal that reflects the expansive range of science represented by AGU’s 62,000 members, including all of the Earth, planetary, and space sciences, and related fields in environmental science, geoengineering, space engineering, and biogeochemistry.
>> Read the full press release here <<
Earth and Space Science joins a prestigious portfolio of research publications that are governed by AGU’s rigorous peer review process. This includes the highly ranked Geophysical Research Letters and Journal of Geophysical Research – Atmospheres, and Earth’s Future—an innovative open access publication that features trans-disciplinary research, editorials, and essays emphasizing the Earth as an interactive, evolving system under the influence of the human enterprise—which was successfully launched in late 2013.
The journal will publish articles under the Creative Commons Attribution License enabling authors to be fully compliant with open access requirements of funding organizations where applicable. The publication fee will be competitive with those of other broad open access journals.
A search is now underway for Earth and Space Science’s inaugural editor in chief, who will lead a team of preeminent academic editors who are closely connected to their communities.
Additional information on Earth and Space Science is available at http://earthspacescience.agu.org.