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Immunity, Inflammation and Disease Publishes Issue 1.1

October 30, 2013

LSJ-12-45832-WOAI-NW-Immunology-Cover-101x131pxWe are pleased to announce that Immunity, Inflammation and Disease has now launched with the publication of its inaugural issue. Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal, providing rapid publication of cutting-edge research across the broad field of immunology.

The Editor-in-Chief, Marc Veldhoen has selected these papers to highlight from the issue:

purple_lock_open Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG by Marie-Laure Bourigault, Noria Segueni, Stéphanie Rose, Nathalie Court, Rachel Vacher, Virginie Vasseur, François Erard, Marc Le Bert, Irene Garcia, Yoichiro Iwakura, Muazzam Jacobs, Bernhard Ryffel and Valerie F. J. Quesniaux
Summary: Here, we confirm that both TNF and IL-1 pathways are required to control M. tuberculosis infection since absence of both IL-1a and IL-1ß recapitulated the dramatic defect seen in the absence of IL-1R1 or TNF. However, presence of either IL-1a or IL-1ß allows some control of acute M. tuberculosis infection. Further, although TNF is essential for the early control of infection by either virulent or attenuated mycobacteria, IL-1 pathway is dispensable for controlling less virulent infection by M. bovis BCG.

purple_lock_open Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways by Kolandaswamy Anbazhagan, Amrathlal Rabbind Singh, Piec Isabelle, Ibata Stella, Alleaume-De Martel Céline, Eliane Bissac, Brassart Bertrand, Nyga Rémy, Taylor Naomi, Fuentes Vincent, Jacques Rochette and Kaïss Lassoued
Summary: PI3K and MAPK exerted opposing effects on the pre-BCR-induced activation of the canonical NF-κB and c-Fos/AP1 pathways. In addition, pre-BCR-induced down-regulation of Rag1, Rag2, E2A and Pax5 transcripts occurred in a PI3K-dependent manner.

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We would like to invite you to submit your immunology paper to the journal. All authors retain copyright in their articles and benefit from high visibility on Wiley Online Library. All articles are fully open access on publication.

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