Have You Read Issue 3 of Physiological Reports?
The latest issue of Physiological Reports has now closed. The issue contains over 30 articles of cutting edge research in Physiology and related disciplines. This is the third issue of this new open access journal and we are delighted by the strength and quantity of submissions so far. The journal graced the publication fee for the first 100 articles which were accepted. 100 articles have now been accepted since our launch in March.
Authors are encouraged to continue to submit their papers to this journal using the online submission site.
The Editor’s Choice papers for this issue are below:
Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6
Miresta Prévilon, Morgane Le Gall, Philippe Chafey, Christian Federeci, Mylène Pezet, Guilhem Clary, Cédric Broussard, Guillonneau François, Jean-Jacques Mercadier and Patricia Rouet-Benzineb
Summary: This two-dimensional differential in-gel electrophoresis proteomic study on pressure overload (PO)–induced cardiac remodeling and heart failure includes the impact of FKBP12.6 over-expression and differentiation of genders. Additionally, differential protein expressions were identified in mice with congestive heart failure (H) compared to non-congested mice (C) and to their respective sham-operated controls-(S), resulting in a total number of 12 individual mouse groups. Bioinformatic analyses showed a predictive huntingtin interactome that is indicative of PO-induced deleterious events in pathological hypertrophy (C) and of the transition to heart failure (H).
Effect of simvastatin in the autonomic system is dependent on the increased gain/sensitivity of the baroreceptors
Edson D. Moreira, Cristiano T. Mostarda, Ivana C. Moraes-Silva, Janaina B. Ferreira, Fernando dos Santos, Silvia Lacchini, Kátia De Angelis, Bruno Rodrigues and Maria Cláudia Irigoyen
Summary: A number of mechanisms have been proposed to explain the pleiotropic effect of statin therapy to reduce sympathetic outflow in cardiovascular disease. The data in this articles suggest that the reduction of sympathetic outflow in hypertension by simvastatin treatment may be triggered by structural changes in the carotid arteries and increased BRS in response to an improvement of the baroreceptors discharge and consequently of the afferent pathway of the baroreflex arch.
Endocrine rhythms in the brown bear (Ursus arctos): Evidence supporting selection for decreased pineal gland size
Jasmine V. Ware, O. Lynne Nelson, Charles T. Robbins, Patrick A. Carter, Brice A. J. Sarver and Heiko T. Jansen
Summary: Plasma melatonin in the brown bear varies with daylength but is present at exceedingly low concentrations. The pineal gland, a major source of melatonin, in the bear is significantly smaller, relative to brain size, than other mammals based on phylogenetic analysis. Cortisol concentrations also varied with daylength.
Podocalyxin regulates pronephric glomerular development in zebrafish
Koichiro Ichimura, Rebecca Powell, Tomomi Nakamura, Hidetake Kurihara, Tatsuo Sakai and Tomoko Obara
Summary: Expression of podocalyxin mRNA in developing pronephric glomerulus. podocalyxin mRNA is detected by in situ hybridization in the paired glomerular primordia at 24 and 34 hpf. Glomerular primordia fuse at the midline to form a glomerulus by 2 dpf, and podocalyxin expression continues in the glomerulus to 2 and 3 dpf.
All the articles in this, and all issues are free to read, download and share.
Visit the website to read all the articles as they publish.