We are pleased to announce that Earth’s Future has launched its first articles. Read the excellent research that we’ve published so far.
Earth’s Future is a new kind of journal – a transdisciplinary open access journal, with a mission to help researchers, policy makers, and the public navigate the science. Earth’s Future focuses on the state of the Earth and the prediction of the planet’s future.
We would like to invite you to submit your papers to the journal. All articles in Earth’s Future are published under a Creative Commons License and are free to read, download and share. So you’ll comply with any funder requirements, and ensure that your work is available to all.
The latest issue of Physiological Reports has now closed. A collaboration between The Physiological Society and the American Physiological Society, the journal offers the highest quality peer review and is proudly open access.
Below are the ‘Editor’s Choice’ articles for this issue:
Inhibitory collaterals in genetically identified medium spiny neurons in mouse primary corticostriatal cultures
Rupa R. Lalchandani and Stefano Vicini
Summary: D1 and D2 MSNs extend inhibitory collaterals that shape neuron firing and striatal output. Using BAC transgenics and paired whole-cell recordings, we describe a paradigm that allows for the simultaneous identification of both MSN subtypes and the targeted study of MSN collaterals.
Cardiac power integral: a new method for monitoring cardiovascular performance
Audun E. Rimehaug, Oddveig Lyng, Dag O. Nordhaug, Lasse Løvstakken, Petter Aadahl and Idar Kirkeby-Garstad
Summary: The continuous product of aortic flow and aortic pressure is the cardiac power curve. The time integral of this curve is the cardiac power integral, and represents the energy transferred from the heart to the aorta. Using a porcine model, we have validated a system for acquiring the cardiac power integral, and found a strong correlation between the cardiac power integral and stroke work across multiple different loading and contractility conditions.
Renal effects of a novel endogenous natriuretic agent xanthurenic acid 8-o-β-d-glucoside in rats
Aaron Hoffman, Marina Okun-Gurevich, Elena Ovcharenko, Ilia Goltsman, Tony Karram, Cristopher Cain, Zaid Abassi and Joseph Winaver
Summary: Xanthurenic glucoside is a new endogenous mild natriuretic/diuretic agent acting on amiloride-sensitive renal epithelial sodium channels. In addition, the in vivo natriuretic effects are partially mediated by NO-dependent mechanisms.
Vascular effects of deletion of melanocortin-4 receptors in rats
David W. Stepp, Christabell C. Osakwe, Eric J. Belin de Chantemele and James D. Mintz
Summary: Obesity causes hypertension, but links remain incompletely understood. Prior studies have suggested that metabolic signals that target melanocortin-4 receptors (MC4R)-expressing neurons in the brain play an important role in linking weight gain to blood pressure. In this study, we demonstrate that in rats genetically devoid of MC4R receptors, morbid obesity fails to produce increases in blood pressure, providing further evidence that MC4R are an important link between increased weight and hypertension.
The journal recently published its 100th article. Find out more about the first 100 articles here.
You can submit your article to Physiological Reports using the online submission site. We look forward to hearing from you soon.
Molecular Genetics & Genomic Medicine has now published its next issue. Editor-in-Chief: Max Muenke introduces his editorial highlights: “Our fourth issue includes some great papers covering the areas of next-generation DNA sequencing for HEXA carrier screening, hemiplegic migraine and the CDC Hemophilia B mutation database. Highlights include the articles, Allelic background of LEPRE1 mutations that cause recessive forms of osteogenesis imperfecta in different populations and Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis.”
Allelic background of LEPRE1 mutations that cause recessive forms of osteogenesis imperfecta in different populations by Melanie G. Pepin, Ulrike Schwarze, Virendra Singh, Marc Romana, Altheia Jones-LeCointe and Peter H. Byers
Summary: LEPRE1 biallelic disease-causing mutations of 44 individuals are described as well as details of background sequences on which the identified mutations occurred. Carrier frequency and LEPRE1 allelic diversity of a Tobago population is reported, confirming a carrier frequency equal to African Americans and similar background sequence variation. The presence of LEPRE1 founder mutations on 7 of the 11 alleles identified in Tobago DNA sequence is consistent with early allele migration out of Africa with founder mutations following.
Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis by Bernd Wollnik and colleages
Summary: Our results provide evidence for a crucial and conserved role of IL11RA during craniofacial development and suture formation. Impaired IL11RA function causes autosomal recessively inherited syndromic craniosynostosis. We propose an inhibitory effect of Il11ra within sutures, thereby preventing their premature fusion.
The journal also publishes invited commentaries. Below is the invited commentary from this issue:
From genetic counseling to “genomic counseling” by Kelly E. Ormond
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The latest issue of Physiological Reports has now closed. The journal is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.
Below are the ‘editor’s choice’ articles for this issue:
The spontaneous electrical activity of neurons in leech ganglia
Majid Moshtagh-Khorasani, Evan W. Miller and Vincent Torre
Summary: Using the newly developed voltage-sensitive dye VF2.1.Cl, we monitored simultaneously the spontaneous electrical activity, which is segregated in three main groups: neurons comprising Retzius cells, Anterior Pagoda, and Annulus Erector motoneurons firing almost periodically, a group of neurons firing sparsely and randomly, and a group of neurons firing bursts of spikes of varying durations. These three groups interact and influence each other only weakly.
The manipulation of strain, when stress is controlled, modulates in vivo tendon mechanical properties but not systemic TGF-β1 levels
Gerard E. McMahon, Christopher I. Morse, Adrian Burden, Keith Winwood and Gladys L. Onambélé-Pearson
Summary: This study describes the manner in which tendon strain during chronic loading/unloading affects tendon dimensional and mechanical properties, as well as muscle function. We also determine the degree of association of these adaptations with a growth factor that has pleiotropic effects on muscle and tendon transforming growth factor beta (TGF-β1). We demonstrate that the impact of strain on the muscle–tendon complex (over and above the absolute stress imposed on this unit) optimizes the magnitude of improvement in both tendon and muscular functional characteristics.
Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: a matter of dose, route, and time
Michael Stephan, Hendrik Suhling, Jutta Schade, Mareike Wittlake, Tihana Tasic, Christian Klemann, Reinhard Pabst, Marie-Charlot Jurawitz, Kerstin A. Raber, Heinz G. Hoymann, Armin Braun, Thomas Glaab, Torsten Hoffmann, Andreas Schmiedl and Stephan von Hörsten
Summary: This article focuses on alteration of asthmatic allergic reaction using a CD26/DPP4 (dipeptidyl peptidase-4) inhibitor in a rat model of asthmatic inflammation. This study proves different effects on clinical signs and cellular inflammation depending on the route of drug administration (chronic via drinking water or inhaled). Aerosolization of the DPP4 inhibitor simultaneously with the allergen significantly reduced airway hyperresponsiveness and ameliorated histopathological signs compared to controls.
Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome
Jason A. Collett, Anne K. Hart, Elaine Patterson, Julie Kretzer and Jeffrey L. Osborn
Summary: Angiotensin II (AII) and its receptors play a major role in the physiology and pathophysiology of blood pressure control. Analysis of different components of the renin–angiotensin system and their heritability was evaluated in a “conplastic” rodent model. AII type 1 receptors, but not other aspects of renin–angiotensin system (RAS) were elevated in the kidneys of hypertensive animals, suggesting a heritable influence of RAS contributing significantly to hypertension.
The jouranl recently published its 100th article. Find out more about the first 100 articles here.
You can submit your article to Physiological Reports using the online submission site. We look forward to hearing from you soon.
The results of Wiley’s open access survey of 8000+ authors were published. You can read a summary of the results on our Exchanges blog site.
We created a data visualization tool so that users can drill into the data by research experience, region, and subject area.
We also produced this infographic which shows key results from our author survey alongside OA results from our librarian survey (conducted in May) as well as Wiley’s own experiences of where authors who choose to publish OA are coming from.
We wrote about the effect that funder mandates are having on the take-up of Wiley’s OA offerings.
Also, during this International Open Access week, we announced the transition of four leading journals from the subscription model to Gold OA from January 2014, bringing the total number of Wiley’s open access titles to 28.
You can also read a comment here from Helen Bray about the role of open communications from publishers in the open science movement.
More about Wiley Open Access can be found on this blog, or here: http://www.wileyopenaccess.com/. And lastly, don’t forget you can follow us at www.facebook.com/wileyopenaccess or tweet us at @WileyOpenAccess
We are pleased to announce that Immunity, Inflammation and Disease has now launched with the publication of its inaugural issue. Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal, providing rapid publication of cutting-edge research across the broad field of immunology.
The Editor-in-Chief, Marc Veldhoen has selected these papers to highlight from the issue:
Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG by Marie-Laure Bourigault, Noria Segueni, Stéphanie Rose, Nathalie Court, Rachel Vacher, Virginie Vasseur, François Erard, Marc Le Bert, Irene Garcia, Yoichiro Iwakura, Muazzam Jacobs, Bernhard Ryffel and Valerie F. J. Quesniaux
Summary: Here, we confirm that both TNF and IL-1 pathways are required to control M. tuberculosis infection since absence of both IL-1a and IL-1ß recapitulated the dramatic defect seen in the absence of IL-1R1 or TNF. However, presence of either IL-1a or IL-1ß allows some control of acute M. tuberculosis infection. Further, although TNF is essential for the early control of infection by either virulent or attenuated mycobacteria, IL-1 pathway is dispensable for controlling less virulent infection by M. bovis BCG.
Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways by Kolandaswamy Anbazhagan, Amrathlal Rabbind Singh, Piec Isabelle, Ibata Stella, Alleaume-De Martel Céline, Eliane Bissac, Brassart Bertrand, Nyga Rémy, Taylor Naomi, Fuentes Vincent, Jacques Rochette and Kaïss Lassoued
Summary: PI3K and MAPK exerted opposing effects on the pre-BCR-induced activation of the canonical NF-κB and c-Fos/AP1 pathways. In addition, pre-BCR-induced down-regulation of Rag1, Rag2, E2A and Pax5 transcripts occurred in a PI3K-dependent manner.
We would like to invite you to submit your immunology paper to the journal. All authors retain copyright in their articles and benefit from high visibility on Wiley Online Library. All articles are fully open access on publication.
We are pleased to announce that Clinical Case Reports has now launched with the publication of its inaugural issue. Clinical Case Reports is a new open access peer reviewed journal publishing case reports and clinical images across all Health Science disciplines.
Editor-in-Chief, Debra Jackson has highlighted two case reports from the issue:
Multiple bone metastases detected 10 years after mastectomy with silicone reconstruction for DCIS and contralateral augmentation by Ryutaro Mori and Yasuko Nagao
Summary: Multiple bone metastases were detected after treatment for ductal carcinoma in situ (DCIS). Contralateral invasive breast cancer was considered to be the metastatic origin.
A perioperative uncontrollable bleeding in an elderly patient with acquired hemophilia A: a case report by Andrea Cortegiani, Vincenzo Russotto, Grazia Foresta, Francesca Montalto, Maria Teresa Strano, Santi Maurizio Raineri and Antonino Giarratano
Summary: A perioperative uncontrollable bleeding referable to an acquired hemophilia A, characterized by a high factor VIII inhibitors titer and a very poor response to bypassing agents and immunosuppressive therapy.
In addition to case reports, the journal also publishes clinical images that illustrate a key clinical finding that can be presented in the form of a question. Below is the highlighted image from the first issue:
What is the diagnosis for this rash? by Namrata Singh and Shireesh Saurabh
Summary: A 46-year-old female with history of Churg-Strauss syndrome was seen for a flare-up.
The rash that she presented with was because of traditional practice called “coining” and this can be confused with physical abuse especially in children and a careful history is needed.
Our aim is to directly improve global health outcomes and share clinical knowledge using case reports to convey important best practice messages. The journal publishes common as well as uncommon clinical scenarios with a particular focus on those reports which illustrate the clinical use of important guidelines and systematic reviews.
We would like to invite you to publish your case report with us.